Determinants of promoter-specific activity by glucocorticoid receptor.
نویسندگان
چکیده
منابع مشابه
Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype.
Differences in glucocorticoid (GC) sensitivity may underlie both common diseases (e.g. hypertension) and variability in response to treatment with GCs (e.g. asthma). We tested the potential involvement of the GC receptor (GR) gene in mediating GC sensitivity using haplotype analysis and a low-dose dexamethasone suppression test. Linkage disequilibrium across the GR gene was determined in 216 U....
متن کاملStimulation of transcription in vitro from a liver-specific promoter by human glucocorticoid receptor (hGRalpha).
The rat tyrosine aminotransferase (TAT) gene is a liver-specific and glucocorticoid-inducible gene. Previous studies have shown that the TAT promoter (TAT0.35; nt -350 to +1) is able to sustain liver-specific gene expression both in transient transfection and in a transcription assay in vitro [Schweizer-Groyer, Groyer, Cadepond, Grange, Baulieu and Pictet (1994) Nucleic Acids Res. 22, 1583-1592...
متن کاملDeterminants of Cell- and Gene-Specific Transcriptional Regulation by the Glucocorticoid Receptor
The glucocorticoid receptor (GR) associates with glucocorticoid response elements (GREs) and regulates selective gene transcription in a cell-specific manner. Native GREs are typically thought to be composite elements that recruit GR as well as other regulatory factors into functional complexes. We assessed whether GR occupancy is commonly a limiting determinant of GRE function as well as the e...
متن کاملThe glucocorticoid receptor blocks P-TEFb recruitment by NF B to effect promoter-specific transcriptional repression
To investigate the determinants of promoter-specific gene regulation by the glucocorticoid receptor (GR), we compared the composition and function of regulatory complexes at two NF B-responsive genes that are differentially regulated by GR. Transcription of the IL-8 and I B genes is stimulated by TNF in A549 cells, but GR selectively represses IL-8 mRNA synthesis by inhibiting Ser2 phosphorylat...
متن کاملThe glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.
To investigate the determinants of promoter-specific gene regulation by the glucocorticoid receptor (GR), we compared the composition and function of regulatory complexes at two NFkappaB-responsive genes that are differentially regulated by GR. Transcription of the IL-8 and IkappaBalpha genes is stimulated by TNFalpha in A549 cells, but GR selectively represses IL-8 mRNA synthesis by inhibiting...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1996
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend.10.10.9121486